The Center for Bioinformatics and Intelligent Medicine team published a paper in
Genomics, Proteomics & Bioinformatics
May 08,2024 Editor：Centre for Bioinformatics and Intelligent Medicine
The lab team published “NeoTCR: an immunoinformatic database of experimentally-supported
functional neoantigen-specific
TCR sequences.” in Genomics, Proteomics & Bioinformatics.
Neoantigen-based immunotherapy has demonstrated long-lasting antitumor activity. The recognition
of neoantigens by T cell receptors (TCRs) is considered a trigger for antitumor responses.
Recent studies have identified a number of functional neoantigen-specific TCRs, but the
corresponding information is scattered across published literature and is difficult to retrieve.
To overcome these challenges, we developed an immunoinformatic database, NeoTCR, which
represents a unique tool to expedite future studies of neoantigen-specific TCRs and the
development of neoantigen-based immunotherapy.
NeoTCR is an immunoinformatic database containing a unified description of publicly available
neoantigen-specific TCR
sequences, as well as relevant information on targeted neoantigens, from experimentally
supported studies across 18
cancer subtypes. It provides users with a convenient way to access neoantigen-specific TCRs and
related information,
including identified and bound neoantigen epitopes, associated gene mutations, and HLA
restrictions. It serves as a
valuable resource for the rapid screening of neoantigen targets and their specific TCR
sequences. Besides, NeoTCR also
provides useful web-based tools for comprehensive analysis of TCR sequencing data that users
upload. In addition, NeoTCR
offers a visualization and analysis tool tool for TCRs. This tool annotates and visualizes TCR
sequence information,
including the V/(D)/J gene segment, CDR3 sequence, clonotype, and so on. NeoTCR also provides an
alignment analysis
tool. It can label the known neoantigen-specific TCRs, and with other public databases (e.g.
VDJdb and McPAS-TCR) to
find out the bystander viral-specific. It serves as a valuable reference for the development and
clinical application of
immunotherapies based on neoantigens. NeoTCR will serve as a valuable platform to study the role
of
neoantigen-associated T-cells in anti-tumor immunity and further improve the understanding of
biological functions and
applications of neoantigen-specific TCRs.
【Source：GPBees】：https://mp.weixin.qq.com/s/ojQA6gDE7O3K0xFKU0utIg